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�й�������־ 2009, 34(11) 691- DOI:   1001-8689��2009��114��691-04  ISSN: 0412-1961 CN: 21-1139/TG

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Study on bacteria in respiratory unit and plasmid mediated drug-resistant gene of Acinetobacter baumannii
1 Department of Microbiology, Faculty of Basic Medical Sciences of Nanchang University, Nanchang 330006 2 Donghu Health Supervising Hygiene, Nanchang 330008
Abstract:

Obejective To analyse the species, distribution and drug resistance of 155 isolates obtained from respiratory unit. To study the drug resistant gene of Acinetobacter baumannii��AB��. Methods The minimal inhibitory concentrations��MICs�� and bacteria were identified by Microscan-autoscan-φ automatic microbe analytic instrument and the results were anzlyzed according to CLSI/NCCLS ��2003�� by WHONET 5.2 software. The analysis of drug-resistant gene on plasmid of AB by PCR. Results Gram-negative bacilli strains accounted for 85.81% in respiratory infection unit. The main pathogen included K. pneumoniae�� 17.29% �� ,AB�� 15.79% �� ,A. lwoffi�� 13.53% ��, P. aerugiinosa�� 11. 28% ��, E. coil��9.77% �� and E. brevis��9.02% ��. The isolate rate of nonfermenting pathogen were increasing, accounted for 45.81% of total isolates,91.61% isolates were isolated from the sputum. Drug resistant rates of Gram-negative bacilli were very high. There was a AB isolates which resistant to 14 usually used antibiotics except imipenem and it��s plasmid harbored three kinds of drug resistant genes that can be transferred and passed stably. Conclusion The serious of bacterial multi-drug resistance is increasing, it is urgent to carry out surveillance of bacterial resistance for use antibiotics reasonably in order to decrease the morbidity rate and fatality rate. Plasmid harboring one or more blaTEM-1, blaPER-1 and blaOXA-23 genes which can be transferred and passed stably is one of the molecular mechanism of multi-drug resistant AB in respiratory infection unit.

Keywords: Respiratory unit    Acinetobacter baumannii     Drug-resistant    Gene    Plasmid  
�ո����� 2008-12-20 �޻�����  ����淢������  
DOI: 1001-8689��2009��114��691-04
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