Objective To investigate the distribution and drug resistance among Gram-negative bacteria from respiratory tract infections during the last two years in our hospital.Methods Of 5914 sputum from Oct 2006 through Oct 2008 in our hospital were collected and analyzed,the API system was used to identify the pathogenic bacteria and conduct antibiotic susceptibility test.Results A total of 1386 Gram-negative bacteria were isolated.The most common microbe causing respiratory infections was P.aeruginosa(31.0%), followed by A.baumannii (14.2% ) , Escherichia coli (12.6% ) , K.peumoniae(11.3%) , E.cloacac (8.4% ) , K.oxytoca (7.6% ) and Stenotrophmomas maltophilia(4.6%). The dominant Gram-negative pathogenic bacteria were sensitive to cefoperazone/sulbactam, and were sensitive to imipenem and meropenem (except Stenotrophmomas maltophilia). The dominant Gram-negative pathogenic bacteria were resistant to ticarcillin、ticarcillin/clavulanic acid、ceftazidime、ciprofloxacin、cefepime、piperacillin/tazobactam、piperacillin、gentamicin and tobramycin. The incidence of ESBLs was 52.8% in K.oxytoca、46.0% in E.coli and 38.5% in K.pneum oniae. ESBLs producing strains were more resistant to penicillin and cephalosp rins than ESBL s of non producing strains. ESBLs producing strains and non ESBLs producing strains were resistant to ticarcillin、cefalotin、trimethoprim/sulfa and amoxicillin but only few strains were resistant to imipenem、meropenem and cefoperazone/sulbactam. Conclusions Drug resistance of isolated pathogenic bacteria from resp iratory tract infection is a serious problem. Monitoring the change of pathogen and the trends of antimicrobial resistance is very important in guiding the antibiotic therapy.
任林, 陈超群, 张秋桂, 谭波. 湖南衡阳地区呼吸道感染革兰阴性杆菌的菌群分布及耐药性分析[J]. J4, 2009, 34(12): 759-.
LIN Lin, CHEN Chao-Qun, ZHANG Qiu-Gui, TAN Bo. Distribution and drug resistance among Gram-negative bacteria from respiratory tract infections. J4, 2009, 34(12): 759-.