Abstract：Objective To analyze the detection rate, the distribution, and trends of multi-drug resistant organism (MDRO) for patients in our whole hospital and intensive care unit (ICU), and to discuss the prevention and control strategies of MDRO infections. Methods Bacteriological monitoring methods were used to analyze the data of 1401 MDRO strains and 189 MDRO strains isolated from the whole hospital and ICU, respectively. Results Among the 1401 MDRO strains in the hospital, the top three MDROs were Escherichia coli, Staphylococcus aureus, and Klebsiella pneumoniae, which were also the main pathogens of MDRO infections in the hospital. Among 669 MDROs (47.8%) of Escherichia coli, 507 strains (75.8%, 507/669) produced ESBLs and 162 strains (24.2%, 162/669) did not produce ESBLs. Besides, there were 184 strains (13.1%, 184/1401) of oxacillin-resistant Staphylococcus aureus (MRSA) and 173 strains (12.3%, 173/1401) of Klebsiella pneumonia, among which 127 strains (73.4%, 127/173) produced ESBLs and 46 strains (26.6%, 46/173) did not produce ESBLs. A total of 189 MDROs were isolated from ICU, accounting for 13.4% of MDRO strains in the whole hospital. The top three MDROs for ICU were 47 strains of Klebsiella pneumoniae, 37 strains of Acinetobacter and 34 strains of Escherichia coli. 39 strains (83.0%, 39/47) of Klebsiella pneumonia and 25 strains (73.5%, 25/34) of Escherichia coli produced ESBLs. The detection rate of MDROs in the hospital showed a downward trend, from 13.0% in 2014 to 7.3% in 2016. The detection rate of MDROs in ICU decreased from 13.4% to 8.6%. Conclusion Respiratory specimens were the main specimen source of MDROs in the hospital and ICU. Strategies should be done to stop the production and spread of resistant bacteria. In addition, it is also important to use antimicrobial drugs rationally, strengthen hand hygiene, and prevent the outbreak of MDROs in hospitals.
