Abstract：Objective To investigate the distribution and antimicrobial resistance of clinical isolates collected from Fujian Jijiang Municipal Hospital in 2016. Methods Clinical isolates were collected from January to December 2016, and antimicrobial susceptibility testing was carried out by using automated systems or the Kirby-Bauer method. Results were analyzed according to CLSI 2016 by the WHONET5.6. Results A total of 1,744 clinical isolates were collected, of which Gram-positive cocci and Gram-negative organisms accounted for 33.8% (590/1,744) and 66.2% (1,154/1,744), respectively. Methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant coagulase negative Staphylococcus (MRCNS) accounted for 29.6% and 72.9%, respectively. The resistance rates of methicillin-resistant (MR) strains to most antimicrobial agents were much higher than those of methicillin-susceptible (MS) strains. No staphylococcal strains were found resistant to teicoplanin and vancomycinor linezolid. In Enterococcus spp., the resistance rates of E. faecalis strains to most of the antibiotics tested (except linezolid) were much lower than those of E. faecium. Two strains of E. faecalis were resistant to linezolid. No E. faecalis or E. faecium strains were found resistant to teicoplanin or vancomycin. The non-meningitis S. pneumoniae strains kept high sensibility to penicillin G. The prevalence of ESBLs producing strains was 50.4% in E. coli and 22.5% in Klebsiella spp.
(K. pneumoniae and K. oxytoca) and 16.7% in Proteus mirabilis isolates. The strains of Enterobacteriaceae were highly susceptible to carbapenems. However, 2.8% of K. pneumoniae were resistant to carbapenems. About 29.7% and 21.2% of P. aeruginosa strains were resistant to imipenem and meropenem. About 60.5% and 62.9% of Acinetobacter spp. (A. baumannii accounts for 94.2%) strains were resistant to imipenem and meropenem, respectively. The prevalence of β-lactamase producing strains was 46.9% in H. influenzae and 99.3% in M. catarrhalis isolates. Conclusion The distribution and antimicrobial resistance of clinical isolates in country hospitals are different from general hospitals.
