Abstract：Objective To provide the basis for effective control and treatment of the infections of Escherichia coli (E.coli) in clinical departments, the drug resistance of E. coli detected in different clinical specimens and different departments in our hospital were analyzed. Methods E. coli from different clinical specimens in our hospital during 2012.01~2016.12 were isolated. The Vitek-2 Compact automatic microbiological analyzer was used for bacterial identification and drug sensitivity test. Results There were a total of 2,241 strains of E. coli separated from different specimens. 1,018 strains (45.4%), 479 strains (21.4%), 387 strains (17.3%), and 290 strains (12.9%) were in urine, secretions, blood, and sputum, respectively. The separation rate in the department of urology was the highest (14.9%). The second and third were ICU (13.3%) and respiratory medicine (13.1%), respectively. The high resistance rate of the specimens in E. coli were mainly detected in urine, sputum, and secretions. High rates of resistance were detected in departments of urology, ICU, and respiratory. Highly resistant E. coli were mainly resistant to piperacillin, cefazolin, cefotaxime, ceftriaxone, levofloxacin, ampicillin, ampicillin/sulbactam, and ciprofloxacin-based drugs. The resistance rates of ceftazidime, cefepime, ceftriaxone, cefotetan, levofloxacin, aztreonam, ampicillin, and ampicillin/sulbactam in different specimens and different departments were statistically significant different (P<0.05). Conclusion It can more accurately reflect the drug resistance status of the strain, better guide the rational use of antimicrobial agents in clinical, and reduce or delay the drug-resistant strains through the analysis of the resistance status of E. coli detected in different specimens and different strains. The results of the study show that clinicians can choose cefoperazone/sulbactam and cefoxitin as the experience drugs in combination with the analysis of different specimens and different rates of resistance among different departments for the treatment of patients infected with E.coli.
展冠军 朱国龙 戴真南 陆瑾*. 临床不同标本及不同科室的大肠埃希菌耐药性分析[J]. 中国抗生素杂志, 2018, 43(6): 734-738.
Zhan Guan-jun, Zhu Guo-long, Dai Zhen-nan and Lu Jin. Analysis of drug resistance of Escherichia coli in different clinical specimens and different departments. CJA, 2018, 43(6): 734-738.
