Abstract：Objective To investigate the susceptibility and resistance of clinical isolates from hospitals in
Sichuan province. Methods Seventy-five hospitals were involved in this program. Antimicrobial susceptibility
testing was carried out according to the Kirby-Bauer method or automated Systems. Results were analyzed according
to CLSI 2017. Results A total of 176576 clinical isolates were collected from January to December 2017, of which
gram negative organisms and gram positive cocci accounted for 70.9% and 29.1% respectively. Methicillin-resistant
strains in S. aureus (MRSA) and coagulase negative Staphylococcus (MRCNS)accounted for an average of 26.8%
and 79.9% respectively. The resistance rates of MR strains to most of other antimicrobial agents were much higher
than those of MS strains. No Staphylococcal strains were found resistant to vancomycin. In Enterococcus spp., the
resistance rates of E. faecalis strains to most tested drugs were much lower than those of E. faecium. A few strains of
both species were resistant to vancomycin. The resistance rate of non-meningitis S. pneumoniae strains to penicillin
was 1.2%. Enterobacteriaceae were still highly susceptible to carbapenems. Overall, less than 9% of these strains were
resistant to carbapenems. About 56.6% and 59.8% of Acinetobacter baumannii strains were resistant to imipenem and
meropenem respectively. About 13.5% and 11.8% of Pseudomonas aeruginosa strains were resistant to imipenem and
meropenem respectively. Conclusions Bacterial resistance to normal antibiotics is still on the rise. It is necessary to
strengthen the surveillance for bacterial resistance to limit the spread of multi-drug resistant bacteria.
