Abstract：Quorum sensing system (QS) is a communication system between microbial cells. Pseudomonas aeruginosa is a typical representative of this system, which regulates bacterial resistance to antibiotics, formation of biofilm, production of virulence factors and attenuating the host immune response. Without affecting bacterial growth, quorum sensing inhibitors (QSIs) could reduce bacterial toxicity and enhance the sensitivity of bacterial biofilm to antibiotic therapy. These characteristics making QSIs to be a research hot spot in the current anti-infective field. This review summarizes the current research advance on quorum sensing system and QSIs of Pseudomonas aeruginosa.
高雅婷1 李晓霞2 段金菊2,*. 铜绿假单胞菌的群体感应系统及其抑制剂研究进展[J]. 中国抗生素杂志, 2018, 43(11): 1338-1343.
Gao Ya-ting1, Li Xiao-xia2 and Duan Jin-ju2. Study on quorum sensing system and its inhibitors of Pseudomonas aeruginosa #br#. CJA, 2018, 43(11): 1338-1343.