Abstract：Objective To analyze the distribution and drug resistance of carbapenem-resistant Enterobacteriaceae (CRE) in clinical specimens in a tertiary children's hospital, and provide reference for clinical anti-infective treatment, prevention, and control of nosocomial infections. Methods The drug susceptibility data and related data of CRE strains were collected from clinical specimens of hospitalized children from January 1, 2015 to December 31, 2017, and the data was statistically analyzed. Results A total of 723 CRE strains were isolated from clinical specimens of hospitalized children. The total detection rate was 15.47%, including 590 strains of Klebsiella pneumoniae, 77 strains of Escherichia coli, and 15 strains of Enterobacter cloacae. The specimen types were mainly 535 sputum, 43 blood sputum, and 35 alveolar lavage fluid. CRE strains were widely distributed, and the main sources of the departments were neonatal intensive care unit, premature infant ward, and pediatric intensive care unit. The resistance rate of CRE to β-lactam antibiotics was more than 90%, and the resistance rate to antibiotics such as aminoglycosides, quinolones and tetracycline was less than 81%. Conclusions The detection rate of CRE strains was high. The clinical distribution of CRE was extensive and the resistance rate to commonly used antibiotics was high. The monitoring and prevention of CRE should be strengthened by Multi-sector linkage, and antibacterial drugs should be used rationally.
