Abstract：Due to the growing resistance of pathogenic bacteria, the effectiveness of traditional antibacterial drugs has generally declined, and the development of novel anti-infective drugs and antibacterial therapies is imminent. Anti-virulence strategies with a focus on fighting bacterial virulence factors has become a new treatment strategy. Unlike traditional antibiotic treatment, antiviral treatment simply deprives pathogenic bacteria of their virulence without inhibiting their growth or killing bacteria. In order to better develop anti-virulence treatment strategies, the understanding of virulence factors needs to be strengthened. This article reviews the research on Gram-negative pathogenic bacteria's aggressive virulence factors, defensive virulence factors, regulation of virulence factor expression, and anti-virulence strategies, with a view to provide ideas for the study of novel and effective antibacterial therapies and the relief of pathogenic bacterial infections and drug resistance.
柏卜鸾 李云鹤 洪守强 王岱*. 革兰阴性病原菌毒力因子及抗毒力治疗策略进展[J]. 中国抗生素杂志, 2021, 46(02): 104-112.
Bai Bo-luan, Li Yun-he, Hong Shou-qiang and Wang Dai . Advances in virulence factors and anti-virulence strategies for Gram-negative pathogens. CJA, 2021, 46(02): 104-112.