Abstract：Objective To investigate the drug resistance and distribution characteristics of Salmonella in
Western China from January 2016 to December 2017, and provide the basis for the rational use of antibiotics in clinical
practice. Methods According to a unified protocol for clinical isolates of Salmonella, the paper diffusion method
or the automated instrument method was used for drug susceptibility tests. The results were interpreted according to
CLSI 2017 standards, and statistical analysis was conducted using the WHONET5.6 software and SPSS23.0 software.
Results The detection rates of Salmonella in Western China in 2016 and 2017 were 0.22% and 0.21%, respectively.
From 2016 to 2017, 256 strains of Salmonella were detected, of which the most detected were Salmonella typhimurium
strains (16.4%), followed by 35 Salmonella typhi strains (13.7%). The drug susceptibility test results showed that the
Salmonella had the highest resistance rate to ampicillin in 2016 and 2017, which were 65.3% and 67.2% respectively,
and the resistance rates to trimethoprim-sulfamethoxazole were 22.5% and 22.6%. The resistance rate to ciprofloxacin
were low, which were 4.0% and 16.2%, respectively. The resistance rates of Salmonella typhimurium to ampicillin and
trimethoprim-sulfamethoxazole were 87.9% and 51.5%, respectively, higher than those of Salmonella typhi(57.1%
and 22.0%), and those of Salmonella enteritidis( 83.3% and 14.3%). Conclusion Salmonella typhimurium and
Salmonella typhi were the predominant Salmonella species in Western China. Salmonella typhimurium had a high
resistance rate, and ampicillin and trimethoprim-sulfamethoxazole are not recommended as the clinical treatment
because of high resistance rates. The third-generation cephalosporins and quinolones antibiotics still maintained a high
sensitivity rate for Salmonella, but it is still necessary to continuously strengthen the monitoring of multidrug-resistant
Salmonella.
