Abstract:As a complex micro-ecosystem in the human body, the gut nicrobiota plays a very important role in maintaining the host physiological functions in maintaining the homeostasis of the human body. It also affects many metabolic diseases, immunity diseases and tumors are closely related to gut microbiota and rational and drug safe treatment have a great significance. This essay analyzes and discusses four aspects of the beneficial and harmful effects of bacteria in the human body, the influence of gut microbiota and health, longevity, disease, and influence on the medicines. The relationship between the gut mocrobiota and different therapeutic types has become a hot research area in recent years, respectively, immunotherapy, chemical drugs, antibiotics and related issues of traditional Chinese medicine, hoping to understand the drug treatment process, scientific and rational use of drugs, the mechanism of drug action, new drug research and development and other research for reference.