Abstract：Carbapenem-resistant Klebsiella pneumoniae (CRKP) is one of the most common drug-resistant bacteria in clinic. In this study, 88 CRKP strains collected nationwide were tested for carbapenems genes. Of which 65 (73.9%) detected blaKPC genes (64 blaKPC-2 and 1 blaKPC-3), nine (10.2%) detected blaNDM gene (all were blaNDM-1) and seven (8.0%) detected blaIMP gene (all were blaIMP-4). By means of multi-locus sequence typing (MLST), 88 CRKP strains were divided into 25 MLST types; of which ST11 type was the dominant type, containing 48 strains. By pulsed field gel electrophoresis (PFGE), 88 CRKP strains were classified into 79 PFGE types, showing high polymorphism. This study revealed that there was cloning of blaKPC-2 positive CRKP strains in China, ST11 clone; while no cloning of blaNDM-1 or blaIMP-4 positive CRKP was observed. We need to closely monitor and take measures to control the spread of blaKPC-2 positive ST11 CRKP strains.