Abstract：To determine the best prescription and preparation technology of posaconazole phospholipid composite submicroemulsion, and confirm it. Phospholipid complex was used as a carrier, and the high pressure homogenization was used to prepare posaconazole phospholipid complex submicron emulsion. Zeta potential, centrifugal stability constant (Ke), content and entrapment efficiency were used as the main evaluation indexes. Single factor investigation and orthogonal optimization were performed on the prescription factors and preparation process factors that affect the submicroemulsion. The sulconazole phospholipid composite submicroemulsion formulation and the preparation process were confirmed. Three batches of samples were prepared according to the prescribed prescription process. The average values of the quality evaluation indexes were as follows: the particle size of 0.186μm, the Zeta potential of -34.69mV, pH at 7.01, the content of 98.12%, the encapsulation efficiency of 91.41%, the osmotic pressure of 302mOsmol/L, in line with submicroemulsion quality requirements. The prescription and the preparation process are simple and feasible, and the reproducibility is good. The prepared submicroemulsion has high encapsulation efficiency, uniform quality and controllability.
郭柳青 芶子杰 陶静* 邓盛齐* 李瑾 蒋芳. 以磷脂复合物为载体的泊沙康唑亚微乳处方及制备工艺研究[J]. 中国抗生素杂志, 2018, 43(6): 715-721.
Guo Liu-qing, Gou Zi-jie, Tao Jing, Deng Sheng-qi, Li Jin and Jiang Fang. Study on the formulation and preparation of posaconazole microemulsion with phospholipid complex as the carrier. CJA, 2018, 43(6): 715-721.