Abstract：Objective To investigate the distribution and drug resistance of Pseudomonas aeruginosa infections in patients with cancer, and guide the rational use of drugs and the prevention and treatment of nosocomial infections. Methods The pathogens and drug resistance of the tumor patients in our hospital from January 2011 to December 2015 were analyzed retrospectively. The drug susceptibility test was conducted using the KB paper method, according to the CLSI. WHONET5.6 analysis was used to analyze the species and drug resistance of pathogenic bacteria. SPSS software was used for statistical analysis. Five year trend of drug resistance rate was analyzed by chi square test. Results The detection rate of Pseudomonas aeruginosa was 3.8%. The sample source was mainly from sputum specimen (29.7%) and endotracheal suction (21.3%). The physical distribution in Department of Oncology (25%), Department of Respiratory Medicine (23.5%), and ICU (19.3%) was high. The resistance to amikacin (7.6%) was the lowest and cefotaxime (47.2%) was the highest, followed by aztreonam (38.1%) and levofloxacin (30.8%). Among them, aztreonam, imipenem, cefotaxime, trend of year by year. There was significant statistical significance in χ2 test (P<0.05). Conclusion The infection rate of Pseudomonas aeruginosa in tumor patients was high, and it showed a rising trend in drug resistance.cefoperazone/sulbactam, piperacillin/three tazobactam showed an increasing
彭克林1,2 黄昌平2 王永生3,*. 2011—2015年自贡市三级综合医院肿瘤患者感染铜绿假单胞菌临床分布及耐药性分析[J]. 中国抗生素杂志, 2018, 43(6): 739-742.
Peng Ke-lin,Huang Chang-ping and Wang Yong-sheng. Distribution and antibiotic resistance of Pseudomonas aeruginosa isolates from patients with cancer in three general hospitals of Zigong from 2011 to 2015. CJA, 2018, 43(6): 739-742.