Abstract：Objective To explore whether intestinal flora imbalance in early life increase the risk of allergic diseases in later stage of life. Methods To repeat intraperitoneal injections of allergen OVA after establishing the mice model of early life intestinal flora imbalance and observe the changes of the serum IgE level, a specific immunological index. Results There was no statistically significant difference in serum IgE levels in three groups of mice before OVA intervention (P>0.05). On 29d, 36d, and 43d, the serum IgE level was significantly higher in the antibiotic high-dose group than in the control group, and the difference was statistically significant (P<0.05). On 43d, the level of serum IgE in the antibiotic low-dose group was significantly higher than that of the control (P<0.05). On 43d, the level of serum IgE in the antibiotic Low-dose group was significantly higher than control group (P<0.05). Conclusion Multiple intraperitoneal injections of OVA sensitization can significantly increase the level of serum IgE in intestinal flora imbalance mice in the early stage of life. The changes of flora structure caused by antibiotic-induced flora imbalance in early life may continue to late life, which will have a lasting effect on the development of immune function in the later stage. It is suggested that the imbalance of intestinal flora in early life may be a risk factor for the increased risk of allergic diseases.
柳园1 王亚娟2 石磊1 龚杰3 廖欣怡3 何方3 胡雯1.*. 生命早期肠道菌群失调与后期过敏性疾病发病风险的研究[J]. 中国抗生素杂志, 2018, 43(6): 743-749.
Liu Yuan1, Wang Ya-juan2, Shi Lie1, Gong Jie3, Liao Xin-yi3, He Fang3 and Hu Wen1. Study on the risk of early life intestinal flora imbalance and later allergic diseases. CJA, 2018, 43(6): 743-749.