Abstract：Abstract Objective To summarize the distribution of Enterococcus and the drug resistance of multiple
drug-resistant strains in 10 tertiary hospitals in Western China in 2016—2017. Methods Using the Kirby-Bauer
disk method or automatic instrument detection method, according to the 2017 standard of the American Clinical
Laboratory Standardization Committee (CLSI), the antimicrobial resistance of Enterococcus isolates from ten
hospitals in Western China in 2016—2017 was analyzed using the WHONET 5.6 software. Results 8,817 nonrepeated
enterococcal bacteria were isolated in 2016—2017years. The top five populations of Enterococcus were
Enterococcus faecium(56.0%), Enterococcus faecalis(37.4%), Enterococcus(1.9%), Enterococcus quail(1.4%), and
Enterococcus yellow Enterococcus (1.2%). The detection rate of enterococci increased in 2 years. Enterococcus was
highly sensitive to linezolid, vancomycin, teicoplanin and tigocycline. The resistance rate was less than 3%. The
resistance rate of Enterococcus faecium was significantly higher than that of Enterococcus faecalis. The resistance rate to
ampicillin, mosifloxacin and levofloxacin was above 80%. The isolated isolates of Enterococcus and non-urine samples
had obvious differences in antimicrobial agents, and the sensitivity to antimicrobial susceptibility of Enterococcus
isolated from different age groups was also significantly different. 8,817 strains of enterococci were isolated in 2016—
2017 years, of which 4,937 strains of high level aminoglycoside resistant Enterococcus (HLARE) were isolated, and
the separation rate was 56%. 86 strains of vancomycin resistant Enterococcus (VRE) were isolated, and the separation
rate was 1%. Among them, 7 and 64 strains of vancomycin resistant Enterococcus faecalis and Enterococcus faecium
were detected. ICU was the main department, accounting for 28%. VRE were isolated mainly from urine specimens,
accounting for 44.2%. In addition to Guizhou and Qinghai hospitals, the number of enterococci isolated in eight other
hospitals in 2017 was higher than that in 2016, and the number of isolated strains of Enterococcus in Xinjiang hospital
was up to 1,459 in the two years. The number of VRE strains in 10 hospitals in Western China was slightly lower than that in
2016, but the number of Enterococcus faeciomycin resistant to vancomycin was more than that in 2017. The VRE detection
rate increased in Chongqing, Guizhou, and Xinjiang hospitals in the recent two years, and The VRE detection rate decreased
in Qinghai, Sichuan, Shaanxi, and Yunnan hospitals. The vancomycin resistant Enterococcus isolation rate was the highest
in Sichuan hospitals during the two years, which was 3.1%. Conclusion In Western China, VRE detection had regional
differences, multidrug resistance was prominent, Enterococcus to profit linezolid, vancomycin, teicoplanin and tigocycline
were still maintain good sensitivity, but the rate of vancomycin resistance in Enterococcus faecalis increased in the two years
and should be paid attention to
