Abstract：Objective To analyze the epidemiological characteristics of neonatal infections of Streptococcus agalactiae in Xinxiang Central Hospital during seven years. Methods Descriptive epidemiological methods were used to retrospectively analyze the clinical data of 16,379 neonates received in our hospital in the past eight years. The differences in the infection rates of Streptococcus agalactiae under different time and demographic characteristics were compared and the drug resistance features of isolated strains were analyzed. Results From 2010 to 2017, a total of 16,379 neonates were received by Xinxiang Center Hospital, of which 61 cases were diagnosed with Streptococcus agalactiae and the annual infection rate was 3.72‰. The infection rate decreased slowly with the year and there was no significant difference in different years between the two groups (P>0.05). The infection rates of Streptococcus agalactiae in the second and third quarters were relatively high, but the difference in infection rates was not statistically significant among quarters (P>0.05). The infection rate of Streptococcus agalactiae in male newborns was slightly higher than that of female newborns (P>0.05). The infection rate of Streptococcus agalactiae was higher in neonates with 32-week-to-gestational age group, and there was a statistically significant difference among different gestational ages (P<0.05). The infection rate of neonatal Streptococcus agalactiae was higher in 1.5kg-to-birth weight group, and there was a statistically significant difference among different birth weights (P<0.05). The infection rate of Streptococcus agalactiae in neonates through vaginal delivery was significantly higher than that of neonates through cesarean section (P<0.05). The infection rate of neonatal Streptococcus agalactiae was higher in 1min Apgar score with 0 point, followed by 4 points~ group, and the difference in different 1min Apgar scores was statistically significant (P<0.05). The results of drug sensitivity test of Streptococcus agalactiae showed that the strain was completely sensitive to cefotaxime, meropenem, linezolid, vancomycin, penicillin, and ampicillin, but resistant to erythromycin (73.77%) and clindamycin (72.13%). Conclusion The infection risk was high in neonates with premature birth, low birth weight, vaginal delivery, and hypoxic signs in our hospital. The clinical sensory control and prevention of Streptococcus agalactiae in obstetrics department can be intervened according to its drug resistance characteristics.
