Abstract：Objective To analyze the influencing factors on the vancomycin trough concentration in neonates and to calculate the relative importance of influencing factors. Methods 107 neonates who received the treatment of vancomycin from January 2016 to December 2017 were included in this study. A retrospective analysis was performed to establish a multivariate linear regression model with the vancomycin serum concentration as the dependent variable. The relative importance of influencing factors was then calculated. Results The final regression model was: C=3.28–0.48WT+0.18Cr–1.15Tau+0.55Dose. The result of relative importance indicated that dosing interval was the most significant covariate (the cumulative contribution rate of correlation coefficient was 50.90%). The cumulative contribution rates of adjusted weight, serum creatinine, and dose per time were 27.00%, 14.60%, and 7.50% respectively. Conclusion The vancomycin trough concentration significantly correlated with dosing interval, adjusted weight, serum creatinine, and dose per time. Compared to dosing interval, higher dose per time increased the trough concentration in a mild manner. Serum creatinine positively correlated to the trough concentration. Further investigations were necessary to identify other potential covariates.
