Abstract：Malaria, transmitted through the bite of an infected anopheles mosquito or by blood transfusion from a malaria infected donor, is a highly infectious disease. Malaria causes symptoms that typically include fever, vomiting, headaches, and even death in severe cases. Antimalarials are indispensable to fight against malaria, but Plasmodium falciparum has already generated resistance to almost all currently accessible antimalarials. To overcome the drug resistance, novel antimalarial agents are needed urgently. Pyrazole derivatives possess diverse biological properties including antimalarial activity, and many pyrazole-containing drugs have already used in clinics for the treatment of various diseases, and thus pyrazole derivatives play a pivotal role in the discovery of new drugs. This review covers the recent advances of pyrazole hybrids as potential antimalarial agents, and the structure-activity relationship is also discussed.