Abstract：Abstract Lincomycin, produced from Streptomyces lincolnensis, is a lincosamide antibiotic. In clinical
practice, lincomycin is mainly used for the treatment of the infection of Gram-positive bacteria. Recently, completion
of the genome sequence of S. lincolnensis has accelerated the development of genetic engineering of lincomycin. This
review firstly summarized the substantial progress about biosynthesis and regulation of lincomycin in recent years.
Secondly, this paper illustrated the application of the modification of structural genes, regulatory genes, resistance
genes and metabolic precursor genes to achieve high yield of lincomycin. Finally, we described the latest progress in
the synthesis of novel lincomycin derivatives by biological methods.
