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�й���������־ 2009, 34(11) 650-653 DOI:   1001-8689��2009��11-0650-04  ISSN: 0412-1961 CN: 21-1139/TG

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Supporting info
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Article by Feng, Z. M.
Article by Tang, Z. R.
Article by Huang, R. L.
Article by Yi, O. L.
[1]�й���ѧԺ���ȴ�ũҵ��̬�о���,���ȴ�ũҵ��̬�����ص�ʵ����,��ɳ410125 [2]�й���ѧԺ�о���Ժ,����100039

������buforin�������������bufo bufo gargarizansθ��֯�з���õ�һ�����Կ����ģ����к�ǿ�Ŀ������ԡ����Ľṹ�Ͷ���α�������������ƣ������û���ȴ�нϴ������Buforin�����������еĽṹ�ڲ����Ĥ���׵������Ѹ��ͨ��ϸ��Ĥ������ڵ��������Ӻ����ϣ��շ�ϸ�����������ľ�buforin��Ľṹ�����û��ƣ��о���״����Ӧ��ǰ�����в�����

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Research progress of buforin ��, a histone H2A-derived peptide
1 Key Laboratory for Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, CAS, Changsha 410125 ; 2 Graduate School of Chinese Academy of Sciences, Beijing 100039

Buforin �� is a potent antimicrobial peptide discovered in the stomach tissue of the Asian toad Bufo bufo gargarizans with strong antibacterial activity. The structure of buforin �� is similar to the most of or-spiral antimicrobial peptides, but with great different mechanisms. Due to its unique structure, Pro Hinge, Buforin �� goes through cell membrane rapidly without causing perforation of cell membrane and interacts with the biological macromolecules, nucleic acid, and induces cell death. The research was done on buforin Irs structure, mechanism, application, present research and advancement.

Keywords: Antimicrobial peptide    Buforin ��    Buforin ��b     Review  
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DOI: 1001-8689��2009��11-0650-04


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