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�й�������־ 2009, 34(11) 3- DOI:   1001-8689��2009��11-00S3-03  ISSN: 0412-1961 CN: 21-1139/TG

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Blood fungal infection: species distribution and drug resistance
Laboratory Diagnostic Center, the First Affiliated Hostlital of Wenzhou Medical College, Wenzhou 325000
Abstract:

Objective To investigate the isolating rate, species distribution and drug resistance of fungal isolates from blood culture in our hospital during the past three years. Methods Blood samples were collected in our hospital between August 2004 and July 2007, cultured with BacT/ALERT 3D, separated with Sobaurand��s agar culture medium, identified with CHROMager medium and VITEK-60 YBC, tested the drug sensitivity with Rosco disk diffusion method. Results Of the specimens in 8707 cases, there were 93 fungal isolates, and the isolating rate was 1.07%. Among the 97 isolates, 41 ��44.09%�� were Candida. albicans, 16�� 17.20% �� were C. tropicalis, 13�� 13.98% �� were C. glabrata. And their drug resistance rates to fluconazole were 2.4%, 6.3% and 23.1%, respectively. All isolates were sensitive to amphotericin B and nystatin. Conclusions The majority of tested strains from blood were C. albicans, followed by C. tropicalis and C. glabrata, C. albicans and C. tropicalis were sensitive to azoles class antifungal agent. C. glabrata was resistant to azoles. Antifungi activity of amphotericin B and nystatin were higher than others.

Keywords: Blood fungal infection   Species distribution   Drug resistance  
�ո����� 2008-12-09 �޻�����  ����淢������  
DOI: 1001-8689��2009��11-00S3-03
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